Subcutaneous (subQ) administration of biologics is increasingly preferred because it enables patient self-administration and reduces healthcare burden.
However, the small dosing volume (up to ~2 mL) pushes monoclonal antibody (mAb) formulations to concentrations of 100 mg/mL and above, where solutions can become highly viscous and prone to aggregation.
This application note explores the viscosity of model solutions comparable to suspensions of spray-dried mAb particles.
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