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We have previously demonstrated the sensitivity of the low shear limiting viscosity to changes in protein pair interactions induced by varying buffer composition. However, characterizing concentrated protein solutions with only a single viscosity value is incomplete. A thorough analysis must include an evaluation of the shear rate dependence to identify the onset and extent of non-Newtonian behavior. Therefore, rate sweeps were performed on a subset of the concentrated Bovine γ-Globulin formulations with a range of low shear plateau values to assess the impact of the protein-protein interactions (PPI) on the full viscosity profile.
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Extremely sensitive! We have done some sample concentration analysis with glycerol and small % changes can impact the viscosity significantly. Here are some sample application notes!
- L-Arginine Viscosity
Yep! Similar to this application note, we have a number of more application notes that focus on various concentrations including higher concentration viscosity solutions. Check them out:
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