High-concentration monoclonal antibody (mAb) formulations are increasingly used for subcutaneous delivery of biologics, offering improved patient convenience over intravenous administration. However, at concentrations above 100 mg/mL, viscosity can rise significantly due to cluster formation, creating challenges for injectability and delivery performance. Establishing quantitative links between viscosity and injection performance is therefore critical for selecting viable formulation candidates.
This webinar explores how shear-dependent viscosity measurements can be used to better understand intermolecular self-association, estimate effective cluster size, and predict injection forces in high-concentration monoclonal antibody (mAb) formulations for subcutaneous delivery. By linking viscosity to injectability, the webinar highlights a practical framework for selecting biotherapeutic formulations with suitable flow properties and improved delivery performance.
