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Webinar: non-Newtonian Scaling Analysis for Protein Solutions

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non-Newtonian Scaling Analysis for Protein Solutions

Shear rate sweeps offer more than just the obvious practical advantages over single point measurements.  A simple scaling analysis of non-Newtonian viscosity data can reveal information about component interactions and microstructure. Download a free recording of our webinar analyzing shear thinning protein solutions to assess the impact of temperature, concentration, and excipient levels. 

This webinar was hosted by our in-house rheologist,  Dr. Stacey Elliott. Stacey obtained her extensive experience and rheological knowledge through her education at Carnegie Mellon University and Princeton as well as her experience at both Alcon and DuPont. 

With her passion for rheology and her belief that rheology is essential for any material, Stacey is a true expert and you don't want to miss her insights on shear thinning! 

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1. What is Viscosity?

Viscosity of often referred to as the thickness of a fluid. You can think of water (low viscosity) and honey (high viscosity). However, this definition can be confusing when we are looking at fluids with different densities.

At a molecular level, viscosity is a result the interaction between the different molecules in a fluid.This can be also understood as friction between the molecules in the fluid. Just like in the case of friction between moving solids, viscosity will determine the energy required to make a fluid flow.  

https://www.rheosense.com/what-is-viscosity

 

2. How many shear rates do you recommend to analyze whether or not your sample is Newtonian or non-Newtonian?

We recommend a minimum of three different shear rates when analyzing your samples to determine whether they are Newtonian or non-Newtonian. Separately, the shear rates should have a wide range. The reason for the wide range is because many are complex. Sometimes, your sample will not show shear thinning or shear thickening behavior at low shear rates but will at high shear rates. 

Overall, there is just a lot to your sample that you may not know about until you actually test it. As a result, we recommend testing as much of a range as possible to ensure full knowledge of how your sample behaves. 

When it comes to your injections, the best way to design your experiments is by focusing on the injection rate that your sample will be exposed to when going from the syringe into a patient. Testing with those numbers in mind will help give you confidence and know what is the unknown.

Questions?

Any questions regarding RheoSense viscometers or general rheology inquiries?
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About the Viscometers

Interested in the viscometer that was mentioned in this webinar? 

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