Rank Your Buffer - Impact of Excipients on Viscosity
How Does Your Buffer Impact Your Data?
In this application note, buffer solutions containing a variety of common additives, including sugars and polymers, were prepared. The viscosity of each was measured to illustrate the ability of the microVISC™ viscometer to differentiate low viscosity fluids to monitor consistency and obtain process validation.
During the protein formulation process, buffer solution serves as one of the core factors in achieving the desired composition. Most viscometers cannot distinguish the consistency of raw materials as well as the formulation process. This application note demonstrates the advantages of measuring with the microVISC™, which incorporates microfluidic and MEMS technology into a portable, small QC viscometer.
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Key Words:
- Viscosity
- Buffer Solutions
- Galactose
- Poloxamer 188
- P 188 Poloxamer
- Trehalose
- Monosaccharide
- Disaccharide
- Formulation Consistency
- Process Validation
- Process Uniformity
- Quality Control
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