We recently published two application notes regarding the importance of viscosity when it comes to working with cell cultures and cell culture media:
Understanding the viscosity of your cell culture media can ultimately determine whether your cell culture will grow and thrive. In addition, being able to characterize the differences between formulations can also help expand into high quality new products.
In this application note, we dive into a deeper look where we take the viscosity data of fetal bovine serum (FBS) and also of cell culture medias supplemented with FBS. Using our automated solution, VROC initium, we were able to gather data where filtering FBS would not change its viscosity and FBS supplementation does change the viscosity of cell and tissue culture media formulations. Being able to characterize formulation to formulation differences as well as batch to batch differences can enhance product development when creating new formulations. This can help benefit cell culture and organ on chip platform powered products.
Cell culture media is a fluid filled with nutrients required for cells to grow. Many aspects are important to it including nutrients, hormones, pH, and osmotic environment for cell growth. A change in viscosity of the cell culture media indicates changes in the media (whether nutrients are intentionally added) or can also indicate that your cell media has changed and it's time to analyze.
Yes! VROC technology can handle non-Newtonian samples by having direct control over shear rates! Newtonian samples are also easy to do!