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Viscosity of Fetal Bovine Serum and Media Formulations




Application Note: Viscosity of Fetal Bovine Serum and Media Formulations

 

We recently published two application notes regarding the importance of viscosity when it comes to working with cell cultures and cell culture media: 

  1. DMEM Cell Culture Media
  2. Viscosity of F12 Cell Culture Media

Understanding the viscosity of your cell culture media can ultimately determine whether your cell culture will grow and thrive. In addition, being able to characterize the differences between formulations can also help expand into high quality new products. 

In this application note, we dive into a deeper look where we take the viscosity data of fetal bovine serum (FBS) and also of cell culture medias supplemented with FBS. Using our automated solution, VROC initium, we were able to gather data where filtering FBS would not change its viscosity and FBS supplementation does change the viscosity of cell and tissue culture media formulations. Being able to characterize formulation to formulation differences as well as batch to batch differences can enhance product development when creating new formulations. This can help benefit cell culture and organ on chip platform powered products.

Key Words: 

  • Cell and tissue culture media 
  • Viscosity of fetal bovine serum
  • Viscosity in product development
  • Viscosity in process development
  • Viscosity modifiers
  • Viscosity of filtration
  • Viscosity in formulation development
  • Automated viscosity measurements
1. How is viscosity relevant to cell culture media?

Cell culture media is a fluid filled with nutrients required for cells to grow. Many aspects are important to it including nutrients, hormones, pH, and osmotic environment for cell growth.  A change in viscosity of the cell culture media indicates changes in the media (whether nutrients are intentionally added) or can also indicate that your cell media has changed and it's time to analyze. 

2. Can RheoSense viscometers do Newtonian and non-Newtonian samples?

Yes! VROC technology can handle non-Newtonian samples by having direct control over shear rates! Newtonian samples are also easy to do! 

About the Viscometer

Learn more about the automated viscometer that compliments Clariti™, VROC® initium.

  • 26 µL of Sampleinitium (no bdg)
  • Sample Retrieval 
  • Sample Recovery
  • Measurement temperatures 4 - 70 ºC
  • Sample storage temperature
  • Intrinsic Viscosity
  • Injectability
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