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Application Note - Predicting Injection Force of Non-Newtonian Monoclonal Antibody Formulations

Injection is a common delivery method for monoclonal antibody (mAb) based therapeutics. 

There are multiple factors to consider when designing and executing viscosity measurements to be used as a predictive tool for the delivery of mAb therapeutics. 

In this application note, shear rate dependent viscosity data was collected with the VROC® initium one plus for eighteen mAb formulations to predict the injection force and compare to the corresponding injection or glide force measurement data. The predictions were made with both a generalized non-Newtonian model and that for a Newtonian fluid using the low shear plateau viscosity.

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Injection Force of non-Newtonian mAbs




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