The viscosity of protein or antibody formulations is often measured to assess injectability. In our next webinar, we will go step-by-step through the process of calculating the injection force from actual viscosity data.
It is quite common for protein solutions to shear thin at rates found within the syringe needle during delivery. Therefore, examples will include both Newtonian and shear thinning protein solutions to clearly illustrate the importance of the viscosity profile on the prediction so that quality candidates are not falsely rejected.
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That is correct! Depending on what you are using from auto-injectors to potentially alternative methods, the injection rate could vary depending on the device, the process of administration, and also potentially the viscosity of your samples. There is no one size fits all when it comes to designing your proteins and also injections - but that's what makes it fun!
We recommend a minimum of three different shear rates when analyzing your samples to determine whether they are Newtonian or non-Newtonian. Separately, the shear rates should have a wide range. The reason for the wide range is because many are complex. Sometimes, your sample will not show shear thinning or shear thickening behavior at low shear rates but will at high shear rates.
Overall, there is just a lot to your sample that you may not know about until you actually test it. As a result, we recommend testing as much of a range as possible to ensure full knowledge of how your sample behaves.
When it comes to your injections, the best way to design your experiments is by focusing on the injection rate that your sample will be exposed to when going from the syringe into a patient. Testing with those numbers in mind will help give you confidence and know what is the unknown.