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Interaction

Protein Protein Interaction & Cluster Size - Analysis at Therapeutic Levels

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Protein-Protein Interactions & Cluster Formation

Measuring viscosity at a single and arbitrary shear rate provides limited information which can be difficult to interpret. A much more thorough understanding of a formulation is obtained by measuring the shear rate dependence. In addition to the practical relevance of predicting the behavior during application or processing, the details of a non-Newtonian response reflect the molecular interactions and resulting microstructure at therapeutic levels. Even protein solutions at moderate concentrations can exhibit a Newtonian plateau followed by a shear thinning region illustrating the importance of non-hydrodynamic forces and degree of structure formation. 

Download the webinar to hear the full review of the non-Newtonian response of protein solutions under steady shear and discussion of options for interpretation. 

 

 

 

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