Viscosity Measurement of mRNA Encapsulated in LNPs

Lipid nanoparticles (LNPs) encapsulating messenger RNA (mRNA) have emerged as a critical delivery system in biopharmaceutical applications, particularly in vaccines, gene therapy, and cancer treatment. These LNPs protect mRNA from degradation and enhance its uptake into target cells.

RheoSense viscometers are powerful tools for advanced rheological analysis of biological fluids. In this application note, we demonstrate how the RheoSense m-VROC® II is used to measure the viscosity of LNP-mRNA during shear rate and temperature sweep experiments.