Viscosity of Nylon 66 in Formic Acid - Concentration & Shear Rate Dependent Studies

Injectability is one of the screening criteria in determining the candidacy of protein therapeutics.  It is determined by the required force during injection.  For a fixed syringe geometry and delivery rate, the required injection force is solely determined by the viscosity of the therapeutics.  (see Higher shear viscosity measurement and injectability application note).  Therefore, candidate protein therapeutics are scrutinized if their viscosity is higher than the pre-set threshold. 

The cut-off viscosity generally ranges from 20 to 40 mPa-s depending on the device.  However, this type of generalization without specifying the shear rate could potentially lead to a false negative determination of an otherwise excellent therapeutic resulting in a significant financial loss during development. 

Learn how to avoid this pitfall with the sequel to our most popular application note, Injectability at High Shear Rates