<img height="1" width="1" style="display:none;" alt="" src="https://dc.ads.linkedin.com/collect/?pid=510762&amp;fmt=gif">

 

 

 

 

Impact of Excipients on

Buffer Viscosity

Buffer Viscosity: The Essential Building Blocks of Formulation
 

Formulate with confidence by building a strong foundation:

Measure buffer viscosity.

It is often desirable to distinguish low viscosity fluids such as buffer solutions prepared to solubilize proteins or antibodies.  Buffers are formulated with a variety of excipients or inactive ingredients to ensure protein stability or to reduce the viscosity without lowering the concentration of the active.  Common additives include mono or disaccharides, sugar alcohols, and individual amino acids.  Since the buffer solution is the foundation of the fully formulated protein, it is important to accurately measure its viscosity.  This will ensure consistency of the raw materials as well as the formulation process.  

Viscosity vs. Concentration with Sucrose

Most viscometers are unable to make such distinctions, and those that are capable tend to be very tedious and time consuming.  This application note demonstrates the advantages of measuring with the VROC® Initium, which incorporates microfluidic and MEMS technology into a fully automated system. 

 ————————————————————————————

Submit form to access full application note.

Key Words:

  • Viscosity
  • Buffer Solutions
  • Arginine Hydrochloride
  • Histidine Hydrochloride
  • Sucrose
  • D-mannitol
  • Trehalose
  • Maltose
  • D-galactose
  • Sugar alcohols
  • Amino Acids
  • Monosaccharide
  • Disaccharide 

 

Check out our application notes!
Application Note Download Form

Banner Image.png

News & Articles


Protein Ageing and Your Solution Shelf Life

Protein solutions are complex fluids in which the rheology can change as the concentration changes. These solutions, used for a wide range of applicat...

Press Release - Introducing VROC® initium one plus

SAN RAMON, CA – August 7, 2020 – RheoSense, Inc. is proud to introduce the new VROC® initium one plus, the leading automatic viscometer that measures ...

More Than Viscosity - Molecular Structure Characterization

When comparing viscometers, the primary differentiators are typically: Does it measure dynamic or kinematic viscosity? Can it measure non-Newtonian sa...

Importance of Viscosity: How to Measure it

In simplest terms, viscosity is defined as “the resistance to flow” and is often referred to as the thickness of a fluid. The concept of a fluid havin...

Google+