Optimization of candidate monoclonal antibodies (mAb) is an essential step in the development of therapeutic formulations. Injectability is a key property required to assess the safety and efficacy of candidate mAb’s. Viscosity of a formulation is the sole parameter that dictates injectability and is thus critically important to characterize during the development process. Highly accurate and reliable viscosity measurements are required during the optimization process.
Since very limited volumes of candidate formulations are normally available early in the development cycle, the ability to accurately and reliably measure viscosity in small samples is vital to success of the development program. In this note, we demonstrate that such accurate and repeatable viscosity measurements of model globular proteins are obtained with 0.5% RSD (relative standard deviation) or better for viscosity fingerprinting using the RheoSense VROC® initium.
VROC® initium offers unattended viscosity measurements at controlled shear rate and temperature. Our most advanced viscometer features:
Download this application note to learn more about how VROC® initium would make your viscosity screening hands free, worry free and Simply Precise™.
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