Predicting Injection Force of Power Law Fluids

Determining the drug delivery pathway is a key component of the development process. There are multiple delivery pathways for drugs that all have tradeoffs that impact the drugs’ ease of use and efficacy. 

Incorporating injectability analysis earlier in therapeutic development can guide development and mitigate the risk of developing a formulation that is impossible to deliver.

If you know the viscosity of your sample as well as the rate of injection and syringe geometry, then you will be able to estimate the injection force. In this application note we will describe a protocol that you can follow to estimate the injection force of your protein formulations using model data taken on the VROC^® initium. We previously addressed how to estimate the hydrodynamic contribution to the injection force for Newtonian fluids. Now we will walk through the injection force estimation for power-law fluids.