Predicting Injection Force of General non-Newtonian Fluids

Determining the drug delivery pathway of candidate drugs is a key component of the development process. There are many potential delivery pathways for drugs each with tradeoffs that impact ease of use and drug efficacy. 

Incorporating injectability analysis earlier in development can guide the process and reduce the risk of creating a formulation that is impossible to deliver.  If you know the viscosity of your sample as well as the rate of injection and syringe geometry, then you will be able to estimate the injection force. In this application note we will describe a protocol that you can follow to estimate the injection force of your protein formulations using model data taken on the VROC^® initium.

We previously addressed how to estimate the hydrodynamic contribution to the injection force for Newtonian fluids and Power Law non-Newtonian fluids. Now, in this application note, we will walk through the injection force estimation for general non-Newtonian Fluids. This general form of the equation can work for both Newtonian and non-Newtonian fluids, but the process to calculating it differs from our previous two examples.