Viscosity is an important fluid property that can be used to predict performance in real world applications. One of the most common uses of viscosity is to assess the ability to deliver pharmaceutical formulations to the patient by injection. A significant component of formulation research and development is rheology modification to ensure that therapeutics can be delivered without an excessive injection force. This concern is especially important when developing high concentration antibody formulations, which can have a broad range of viscosities depending on the specific protein-protein interactions. To tackle the problem of relating viscosity to injection force, we turn to fluid mechanics for pressure driven flow through a circular cross section.
Our new 5 part application note series covers everything you need to know about injection force predictions from theoretical foundation (general syringe geometry and the equations) to protocols that you can follow to estimate the injection force of Newtonian fluids, Power Law fluids, and General non-Newtonian fluids.