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Viscosity Measurement of a Model Protein Solution of BSA

A study was conducted where bovine serum albumin (BSA) was used as a model protein to measure viscosity as a function of concentration and shear rates.

The objective with this study was to determine the effect of the shear rate on the viscosity of the model protein, as measured by the VROC® technology. For the purposes of the study, high concentrations of the BSA protein were used to analyze the measurement results of protein loading in delivery. The BSA in plasma is approximately 50 mg/mL. For this study, the measured concentration of BSA varied between 1.2 mg/mL and 404 mg/mL.Protein(2)

The study used RheoSense’s VROC® (Viscometer-Rheometer-on-a-Chip) technology to measure viscosity from the pressure drop as the test solution flowed through a regular slit. The test solution consisted of the sample BSA, which was diluted with phosphate-buffered saline at various concentrations.

The study considered the viscosity versus the shear rates of each concentration, as well as viscosity as it applied to the concentration of the test solutions.

Download the application note for the full study and illustrations.