Concentrated Protein Solutions: Temperature Dependent Viscosity

This application note aims to determine the viscosity of a concentrated protein solution at temperatures relevant to sample preparation, storage, processing, and delivery by presenting viscosity analysis protocols for concentrated protein solutions, which often times are limited to a single measurement point near room temperature or 25°C.  Although this is relevant to the formulation process and perhaps even delivery, the value of measuring viscosity at additional temperatures should not be overlooked.

KEYWORDS:

• Viscosity
• Concentrated Protein Solution
• Bovine Gamma Globulin
• Arrhenius Equation
• Temperature Sweep