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Rheology Tools: Calculating Peclet Number

Application Note Download

Determining protein cluster size as a function of formulation composition is important during drug development. The effective size and spacing of proteins can be larger than the hydrodynamic radii determined by characterization techniques such as Dynamic Light Scattering. One such method to determine cluster size of concentrated protein solutions is by scaling shear rate dependent viscosity data. Specifically, the shear rate is converted to the non-dimensional Peclet number.

Protein(2)

In this application note, we will step through how to perform this analysis to estimate the relative cluster size of proteins in various formulations.



 

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