--- title: Protein Therapeutics Viscosity | Small Sample Viscometer description: Viscosity readings by our small sample viscometers improve protein delivery and improve dynamic light scattering particle size measurements accuracy. --- [![RheoSense company logo - viscometer](https://www.rheosense.com/hs-fs/hubfs/Logo/RegLogo.png?width=258&name=RegLogo.png "RegLogo.png")](https://www.rheosense.com/viscometer?hsLang=en) ![inner-banner-image.png](https://www.rheosense.com/hs-fs/file-874204808-png/images/inner-banner-image.png?width=997&name=inner-banner-image.png "inner-banner-image.png") ## Application Notes— Proteins and Small Samples Obtaining accurate viscosity values of proteins therapeutics is becoming more important for formulating therapeutic drugs due to the high protein concentrations in drugs. Read about it: - [High Shear Viscosity & Injectability](https://www.rheosense.com/drug-injections-viscosity?hsLang=en) - [Viscosity measurement of a Model Protein Solution of BSA (Bovine Serum Albumin)](https://www.rheosense.com/application-protein-bsa?hsLang=en) - [Viscosity Measurement of Gamma Globulin Solution in PBS](https://www.rheosense.com/hs-fs/hub/296746/file-1202194761-pdf/VROC-APP-05_(5-08)_Viscosity_Measurement_of_Gamma_Globulin_from_Bovine_Blood.pdf?hsLang=en) - [Protein Unfolding and Denaturing Study with VROC®](https://www.rheosense.com/protein-unfolding-denaturing-study?hsLang=en) - [Protein Formulation Stability - No Dilution Required](https://www.rheosense.com/hs-fs/hub/296746/file-1200463954-pdf/m-VROC-APP-10_(4-10)_Protein_Formulation_Stability_Probe_with_VROC.pdf?hsLang=en) - [Protein Formulation Stability - Sucrose Effect](https://www.rheosense.com/hs-fs/hub/296746/file-1208441007-pdf/VROC-APP-12_(5-10)_Protein_Formulation_Stability_with_VROC_-_Sucrose_Effect-1.pdf?hsLang=en) ### Eye Drop - Viscosity - [Viscosity of Eye Drop](https://www.rheosense.com/impact-of-viscosity-on-eye-drop-retention?hsLang=en) ## RheoSense Viscometers Powered by[ VROC®](https://www.rheosense.com/technology?hsLang=en) technology, [*micro*VISC™](https://www.rheosense.com/products/microvisc/overview?hsLang=en) and [*m-*VROC](https://www.rheosense.com/products/m-vroc/overview?hsLang=en)[™ ](https://www.rheosense.com/products/m-vroc/overview?hsLang=en)are both small sample viscometers capable of improving your viscosity measurements for protein delivery. [![m-VROC Small Sample Viscometer](https://www.rheosense.com/hs-fs/hub/296746/file-1207744865-png/Product_Folder/LM3.png?width=278&name=LM3.png "m-VROC Small Sample Viscometer")](https://www.rheosense.com/products/m-vroc/overview?hsLang=en) [![Portable, small sample viscometer microVISC](https://www.rheosense.com/hs-fs/hub/296746/file-1200669124-png/Product_Folder/DSC_0052_with_logo_(top_right).png?width=278&name=DSC_0052_with_logo_(top_right).png "Portable, small sample viscometer microVISC")](https://www.rheosense.com/products/microvisc/overview?hsLang=en) [![Consult an Expert](https://hubspot-no-cache-na2-prod.s3.amazonaws.com/cta/default/296746/e0712c72-7b05-4236-ba78-244ff4f47ea2.png)](https://hubspot-cta-redirect-na2-prod.s3.amazonaws.com/cta/redirect/296746/e0712c72-7b05-4236-ba78-244ff4f47ea2) # **Protein Therapeutics** ## Viscosity and Protein Therapeutics Protein Therapeutics and its associated disciplines, such as antibody therapeutics and [RNA therapeutics](https://www.rheosense.com/rna-therapeutics-viscosity?hsLang=en), are the fastest growing segments in the biotechnology market. The industry has come a long way since breakthroughs in human insulin recombinant DNA technology in the 1980s. Today protein therapeutics can be classified by their molecular types: - Antibody-Based Drugs - Anticoagulants - Blood Factors - Bone Morphogenetic Proteins - Engineered Protein Scaffolds - Enzymes - Fc Fusion Proteins - Growth Factors - Hormones - Interferons - Interleukins - Thrombolytics   ## VROC® Powered Viscometers Improves Protein Delivery ![Vial](https://www.rheosense.com/hs-fs/hub/296746/file-1176689216-png/images/Vial.png?width=225&name=Vial.png "Vial")RheoSense, with its [VROC](https://www.rheosense.com/technology?hsLang=en)[®](https://www.rheosense.com/technology?hsLang=en) technology, measures viscosity to improve efficacy, maximize safety, and improve delivery. By providing key data, [VROC](https://www.rheosense.com/technology?hsLang=en)[®](https://www.rheosense.com/technology?hsLang=en) offers unique insights into the behavior of protein solutions, while accommodating the typical constraints of research laboratories.  - Requires very small sample size — this is ideal when the total solution volume is limited  - Maintains accuracy through a wide range of temperature and shear rates — this is important when researchers are trying to understand the nature of new or modified proteins - Makes dynamic light scattering particle size measurements more accurate — the analysis in behavior of complex solutions with accurate viscosity data can be used in the calculation of the coefficient of diffusion, reducing error by up to 30%!  ## Fast, Accurate, Non Destructive: The Right Viscosity Measurement Makes a Difference [VROC](https://www.rheosense.com/technology?hsLang=en)[®](https://www.rheosense.com/technology?hsLang=en) powered viscometers are the preferred solution for measurement of protein formations for some of the largest pharmaceutical companies in the world, because it is fast, accurate, and non-destructive.  Its fast measurement capabilities allow researchers to easily run tens of samples per day. It is a small volume viscometer and can accurately measure viscosity with sample volumes as small as 20 µL. The instrument is designed to allow almost full sample recovery for further analysis. This makes RheoSense viscometers an ideal, fast, non-destructive method for viscosity measurements on expensive samples which are available in limited volumes.  ## Simple, Precise Extraction and Measurement with RheoSense Viscometers The sample is introduced to [VROC](https://www.rheosense.com/technology?hsLang=en)[®](https://www.rheosense.com/technology?hsLang=en) via a syringe and into the sealed measuring cell, so the sample is never exposed to air. The presence of the liquid-air interface is known to be the source of protein aggregation and precipitation, which can negatively impact the accuracy of viscosity measurements. The sealed configuration in the viscometer prevents the formation of foams, surface films and other undesired effects such as sample oxidation and contamination.  ![Injections](https://www.rheosense.com/hs-fs/hub/296746/file-1374176973-jpg/1-2.jpg?width=409&name=1-2.jpg "Injections") RheoSense's innovative rectangular slit method of measuring true viscosity is listed in the US Pharmacopeia and combines MEMS and microfluidic technologies to deliver data with the highest accuracy and repeatability. 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