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Application Notes— Proteins and Small Samples

Obtaining accurate viscosity values of proteins therapeutics is becoming more important for formulating therapeutic drugs due to the high protein concentrations in drugs. Read about it:

Eye Drop - Viscosity

RheoSense Viscometers

Powered by VROC® technology, microVISC™ and m-VROCare both small sample viscometers capable of improving your viscosity measurements for protein delivery.

m-VROC Small Sample Viscometer

Portable, small sample viscometer microVISC

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    Protein Therapeutics

    Viscosity and Protein Therapeutics

    Protein Therapeutics and its associated disciplines, such as antibody therapeutics and RNA therapeutics, are the fastest growing segments in the biotechnology market. The industry has come a long way since breakthroughs in human insulin recombinant DNA technology in the 1980s. Today protein therapeutics can be classified by their molecular types:

    • Antibody-Based Drugs
    • Anticoagulants
    • Blood Factors
    • Bone Morphogenetic Proteins
    • Engineered Protein Scaffolds
    • Enzymes
    • Fc Fusion Proteins
    • Growth Factors
    • Hormones
    • Interferons
    • Interleukins
    • Thrombolytics


    VROC® Powered Viscometers Improves Protein Delivery

    VialRheoSense, with its VROC® technology, measures viscosity to improve efficacy, maximize safety, and improve delivery. By providing key data, VROC® offers unique insights into the behavior of protein solutions, while accommodating the typical constraints of research laboratories. 

    • Requires very small sample size — this is ideal when the total solution volume is limited 
    • Maintains accuracy through a wide range of temperature and shear rates — this is important when researchers are trying to understand the nature of new or modified proteins
    • Makes dynamic light scattering particle size measurements more accurate — the analysis in behavior of complex solutions with accurate viscosity data can be used in the calculation of the coefficient of diffusion, reducing error by up to 30%! 

    Fast, Accurate, Non Destructive: The Right Viscosity Measurement Makes a Difference

    VROC® powered viscometers are the preferred solution for measurement of protein formations for some of the largest pharmaceutical companies in the world, because it is fast, accurate, and non-destructive. 

    Its fast measurement capabilities allow researchers to easily run tens of samples per day. It is a small volume viscometer and can accurately measure viscosity with sample volumes as small as 20 µL. The instrument is designed to allow almost full sample recovery for further analysis. This makes RheoSense viscometers an ideal, fast, non-destructive method for viscosity measurements on expensive samples which are available in limited volumes. 

    Simple, Precise Extraction and Measurement with RheoSense Viscometers

    The sample is introduced to VROC® via a syringe and into the sealed measuring cell, so the sample is never exposed to air. The presence of the liquid-air interface is known to be the source of protein aggregation and precipitation, which can negatively impact the accuracy of viscosity measurements. The sealed configuration in the viscometer prevents the formation of foams, surface films and other undesired effects such as sample oxidation and contamination. 


    RheoSense's innovative rectangular slit method of measuring true viscosity is listed in the US Pharmacopeia and combines MEMS and microfluidic technologies to deliver data with the highest accuracy and repeatability.