Obtaining accurate viscosity values of proteins therapeutics is becoming more important for formulating therapeutic drugs due to the high protein concentrations in drugs. Read about it:
Protein Therapeutics and its associated disciplines, such as antibody therapeutics and RNA therapeutics, are the fastest growing segments in the biotechnology market. The industry has come a long way since breakthroughs in human insulin recombinant DNA technology in the 1980s. Today protein therapeutics can be classified by their molecular types:
RheoSense, with its VROC® technology, measures viscosity to improve efficacy, maximize safety, and improve delivery. By providing key data, VROC® offers unique insights into the behavior of protein solutions, while accommodating the typical constraints of research laboratories.
VROC® powered viscometers are the preferred solution for measurement of protein formations for some of the largest pharmaceutical companies in the world, because it is fast, accurate, and non-destructive.
Its fast measurement capabilities allow researchers to easily run tens of samples per day. It is a small volume viscometer and can accurately measure viscosity with sample volumes as small as 20 µL. The instrument is designed to allow almost full sample recovery for further analysis. This makes RheoSense viscometers an ideal, fast, non-destructive method for viscosity measurements on expensive samples which are available in limited volumes.
The sample is introduced to VROC® via a syringe and into the sealed measuring cell, so the sample is never exposed to air. The presence of the liquid-air interface is known to be the source of protein aggregation and precipitation, which can negatively impact the accuracy of viscosity measurements. The sealed configuration in the viscometer prevents the formation of foams, surface films and other undesired effects such as sample oxidation and contamination.
RheoSense's innovative rectangular slit method of measuring true viscosity is listed in the US Pharmacopeia and combines MEMS and microfluidic technologies to deliver data with the highest accuracy and repeatability.