Thermosenstive Polymers as Pharmaceutical Excipients

This application note presents viscosity profiles as a function of shear rate and temperature for a Poloxamer 407 (Lutrol® F 127) solution. 

Viscosity is highly sensitive to solution microstructure and ideal for characterization of temperature sensitive triblock copolymers.  Variations with temperature can be correlated to structural rearrangement such as micelle formation and packing.  Viscosity monitoring provides critical transition temperatures so that intelligent formulation to suit specific applications is a reality.   

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Excipients
KEY WORDS
  • Viscosity
  • Rate Sweep
  • Temperature Sweep
  • Triblock Copolymer
  • Polymeric Excipient
  • Poloxamer/Lutrol
  • Thermosensitive Polymers
  • Self-Assembly
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No viscometers were harmed in this experiment

m-VROC® , our small sample R&D viscometer, was used to obtain the data generated in this application note. The main reasons for using  m-VROC® is due to the capabilities of a wide shear rate range and accuracy. Through the software, we were able to conduct shear rate and temperature rate sweeps of the Poloxamer 407 (Lutrol® F 127) solution. As stated above, the ability to conduct viscosity easurements can be used to optimize formulation coposition and achieve desired temperature dependent viscosity changes. 

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