Where does viscosity fit when it comes to Hospitals and Medical Device Industries?

Protein-based drugs are the fastest growing class of drugs for the treatment of many diseases in humans, ranging from cancer to Alzheimer’s disease. Accurate viscosity values of proteins are essential in understanding behavior, designing delivery systems, and accurately determining particle size/hydrodynamic radius. 

VROC^® powered viscometers deliver accurate and reliable viscosity results that are required to understand behaviors of antibodies and other proteins. By applying a wide range of viscosities and shear rates, you can gain a full length range of insight into your proteins.

Remember VROC^® technology :

• Smallest sample volumes
• Direct shear rate control
• First principle or true viscosity 

Check out all of our application notes separated into major topics: 

• Formulation
• Protein Screening
• Antibody Therapeutics
• Drug Delivery
• Protein Stability
• RNA Therapeutics
• Hydrodynamic Radius
• Whole Blood/Blood Plasma/Blood Serum
• Ophthalmic Solutions

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Protein Formulation Requires Stability & Efficacy

Working with various protein candidates, buffers, adding excipients, etc, check out the application notes that we have published that are important to formulation.

• Formulation of Eye Drops with Shear Rate Dependence (Opthalmic Formulation)
• Concentrated Protein Solutions - Temperature Dependent Viscosity
• Monitoring Stability of Concentrated Protein Solutions
• Viscosity of Thermosensitive Pharmaceutical Excipients
• Viscosity Reduction in Protein Solutions
• How do Your Proteins Interact? 
• Optimization of Protein Formulation Complete Viscosity Characterization of Gamma-Globulin and Serum Albumin Solutions - Viscosity Fingerprinting and Analysis
• Automated Temperature Sweeps
• Automated Viscosity Screening Through Temperature Sweeps
• Automated Screening: BSA Viscosity Versus Concentration and Temperature
• Intrinsic Viscosity Measurement for Optimal Therapeutic Formulation
• Measurements with 18 µL of Sample
• Sample Retrieval: 20 Different Shear Rates with 18 µL of Sample
• Impact of Excipients on Buffer Viscosity
• High Concentration of Biologics
• Protein Formulation Stability Probe with VROC
• Thermosensitive Polymers as Pharmaceutical Excipients
• Viscosity vs. Concentration: L-Arginine Dilute Solutions in Water and PBS
• Gamma Globulin from Bovine Blood
• Protein Formulation Stability - Sucrose Effect
• Rank Your Buffer - Excipient Impact on Viscosity
• Injectability
• The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls

Screening for Protein-Protein Interaction

• Probing Microstructural Changes with Viscosity Measurements
• How do Your Proteins Interact? 
• Intrinsic Viscosity for Optimization of Protein Therapeutics
• Repeatable Viscosity Measurements for Protein Candidate Screening
• Automated Temperature Sweeps
• Automated Viscosity Screening Through Temperature Sweeps
• Automated Screening: BSA Viscosity Versus Concentration and Temperature
• Impact of Excipients on Buffer Viscosity
• Thermosensitive Polymers as Pharmaceutical Excipients
• Viscosity vs. Concentration: L-Arginine Dilute Solutions in Water and PBS
• Protein Unfolding or Denaturation Study
• The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls

Drug Delivery Systems

Administration of a drug is not limited to one method, there are different approaches, formulations, and delivery that all contribute to efficacy. Viscosity of the formulation can impact efficacy in many different ways. Learn more: 

• Optimization of Protein Formulation Complete Viscosity Characterization of Gamma-Globulin and Serum Albumin Solutions - Viscosity Fingerprinting and Analysis
• High Resolution Automatic Viscometer Distinguishes Injectability of Candidate Proteins at an Early Stage of Development
• Injectability Tutorial Accurate Estimation of Injectability from High Shear Viscosity
• The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls

Characterization of Proteins 

Hydrodynamic radius (Rh) is a common parameter used to describe a molecule's size. Understanding the characteristics of proteins can help understand protein behavior as proteins can be quite complex.

• Intrinsic Viscosity Analysis of Protein Solutions
• Can Your Proteins Take the Heat? 
• How do Your Proteins Interact? 
• Intrinsic Viscosity for Optimization of Protein Therapeutics
• Ionic Strength Affects Protein Stability in Solution
• Optimize Your Formulations: Intrinsic Viscosity Measurements of Protein Solutions with VROC^® initium
• Intrinsic Viscosity Measurement for Optimal Therapeutic Formulation
• Single Point Intrinsic Viscosity
• Intrinsic Viscosity/Hydrodynamic Radius