This single day event brought together a panel of speakers for from both industry and academia to facilitate the discussion of rheology fundamentals with a focus on viscosity applications. Our speakers shared their rheology expertise and discussed various viscosity applications, building awareness of the significance of viscosity across their industries.
Interactions, Clustering, and Rheology of Highly Concentrated Antibody Solutions
Keith Paul Johnston, PhD, Professor, University of Texas at Austin
Amjad Akif Chowdhury, McKetta Department of Chemical Engineering, University of Texas at Austin Graduate Research Assistant
Highly concentrated therapeutic antibody solutions are desired for subcutaneous delivery, but exhibit prohibitively high viscosities. Here, we discuss the effect of pH and additional cosolutes on the viscosity of antibody solutions, and characterize the underlying interactions and clustering that determine viscosity using small angle x-ray scattering (SAXS), coarse-grained molecular dynamics simulations, and shear rheology.
The Use of Viscosity in the Development of Pharmaceutical Biologics
Barton Dear, PhD, Scientist, Bristol Myers Squibb
Due to high dosage requirements many biologic pharmaceuticals are formulated at high concentrations (>100 mg/ml) for subcutaneous injection. Additionally, these solutions are typically stored at refrigerated temperatures (2-8oC) to maintain stability. The viscosities of these solutions are exponential in both time and temperature, leading to wide ranges in solution viscosity among solutions that are within specification in concentration (typically ±~10%) and warming up from refrigerated to room temperature (between 5 and 25 oC). These viscosity ranges affect both the administration of the product, whether manually or by a device, as well as the production and processing during filtration, mixing, etc. Therefore, for any high concentration biologic understanding the entire product viscosity profile is essential.
Some Factors Effecting the Viscosity of High Molecular Weight Water Soluble Polymers
Carl Aften, PhD, Principal Polymer Scientist, SNF Holding Company
Dr. Aften has been responsible for product introduction mainly of high molecular weight water soluble polymers, mainly drag reducers, gelling and viscosifiers, but also clay stabilizers, biocides, scale inhibitors, foamers, cement additives, pH control , crosslinkers, breakers, controlled release, retention and strength aides in the technical realms of oil and gas, waste water, pulp and paper, textile, and mining. He has been using instruments from RheoSense since 2011.
Viscosity of Food Products
Shamsheer Mahammad, PhD, Senior Principal Rheologist, Kraft-Heinz
Consumers like food products that have the right flowability, scoopability, spoonability and shelf stability. Viscosity measurements play a major role in ensuring that the food products have the right textural attributes that the consumers prefer.
Optimizing Formulation Development: Understanding Viscosity’s Role in the Formulation Process and How to Create a Measurement Plan
Stacey Elliott, PhD, Principal Scientist, RheoSense
Zachary Imam, PhD, Research Scientist, RheoSense
The other summit speakers have all illustrated the importance of establishing structure-property relationships for their industry or application. Intentional formulation to influence component interactions and the resulting microstructure leads to the ultimate goal of controlling physical properties, such as viscosity, and the ability to predict performance. We present case studies involving a variety of rheology modifiers to demonstrate their role in the formulation process and how VROC® technology can enable a thorough viscosity evaluation of complex fluids. The presented material will also emphasize the importance of defining goals at the start and creating a measurement plan to achieve them.
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