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Application Note: Concentrated Protein Solutions 

Exploring Temperature Dependent Viscosity

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This application note aims to determine the viscosity of a concentrated protein solution at temperatures relevant to sample preparation, storage, processing, and delivery by presenting viscosity analysis protocols for concentrated protein solutions, which often times are limited to a single measurement point near room temperature or 25°C.  Although this is relevant to the formulation process and perhaps even delivery, the value of measuring viscosity at additional temperatures should not be overlooked.

 

KEYWORDS:

  • Viscosity
  • Concentrated Protein Solution
  • Bovine Gamma Globulin
  • Arrhenius Equation
  • Temperature Sweep

 

1. Does temperature affect viscosity?

Temperature is a huge important factor when it comes to viscosity. At high temperatures, the natural tendency of materials is to become more fluid-like and cause viscosity to go down. At lower temperatures, the natural tendency of materials is to become more viscous causing the viscosity to go up.  That's why many temperature dependent studies are conducted on various types of samples in all types of industries. 

We encourage our customers to measure various parameters including various temperatures especially if your samples are going to be going through temperature changes via transport, various laboratories, going from manufacturing to final product, manufacturing processes in general, and so much more!

2. Do proteins denature at a certain temperature?
Yes, proteins, including Bovine Gamma Globulin, denature at a certain temperature. Formal studies also known as "denaturation studies" are conducted all the time. While it is good to see how your product behaves ultimately, it is also good to see how your product will fail and when it will fail. 
3. What benefits does VROC Technology have over others?

VROC® technology works in a fully enclosed system. This is beneficial as it will not be affected by air causing your viscosity values to be higher or lower and you will not see any strange behavior of your sample as air interacts during measurement. 

Learn more via http://www.rheosense.com/technology 

About the Viscometer

Learn more about the automated viscometer that compliments Clariti™, VROC® initium.

  • 26 µL of Sample
  • Sample Retreival initium (no bdg)
  • Sample Recovery
  • Measurement temperatures 4 - 70 ºC
  • Sample storage temperature
  • Intrinsic Viscosity
  • Injectability 
VROC initium
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